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🐾 Keep your pet’s ears happy, healthy, and infection-free—because prevention is the new cure!
Zymox Advanced Formula Otic Plus is a cutting-edge enzymatic ear solution for dogs and cats that combines the LP3 Enzyme System with 1% Hydrocortisone to effectively clear biofilms, soothe itching, and reduce redness. Its gentle, no pre-cleaning formula offers a natural, vet-trusted alternative to antibiotics, helping prevent stubborn ear infections and promoting lasting ear health for pets of all ages.






































| Customer Reviews | 4.7 out of 5 stars 15,270 Reviews |
A**T
The most awesome item on Amazon
My poor goldendoodle has had chronic ear infections since she got anaplasmosis from a tick bite (while on simpirica trio!). The last one in January turned antibiotic resistant. Every time we bring her to the vet, they give keto solution or otic. Her ears were so swollen the stuff doesn’t even get in there! They put her on steroids that made her crazy and still the infection turned worse. The keto solution sits in there making it a wet environment (if they are swollen some will seep down and they can’t shake it out due to swelling, or it just sits on the outside making the ear moist in general), perfect for fungus and bacteria to breed. After thousands of dollars and 3 vets all wanting to do things that don’t work or fix the CAUSE, I decided to not put any more cleaning fluids in (thank goodness for AI helping me make this decision) and just opt for this product when she starts getting itchy which is maybe once a month on air quality alert days. After her last course of topical, oral antibiotics and steroids which usually gave her two weeks of clear ears, I was prepared for another battle. She had 30 days of doxy, 14 days of another one and 7 days of another antibiotic! This destroyed her immune system. All of this because her Simpirica Trio did not work that is 200 for 6 pills (is this a scam?). And vets are not motivated to fix things since they would not have a job without chronic issues. I knew it would be rough. 2 weeks after treatment, like clockwork, her ears started back up. Instead of cleaning them more and taking her back to the vet, I got this stuff. Bam! It’s been 7 months without an infection. I also put her on Proplan fortiflora, proviable probiotics and I make sure her food doesn’t have corn, soy, wheat, or a lot of rice. A lot of the foods that VETS recommend are loaded with filler carbs! Carbs feed bacteria and yeast! Dogs need carbs, obviously just like we do but quality is important. Her food has better carbs like carrots and fruits so she still has energy. She still has itchy days because we cannot control all of her variables and she is still healing from the anaplasmosis, but dang this stuff works to keep her out of the vet and treatments that not only didn’t help, but made it worse. This actually worked to prevent infection and the probiotics have been instrumental in helping her overall immune system. Not only did it prevent infection for her but anytime she gets itchy, it helps in a matter of minutes and she can’t shake it out, it’s easy to drop in and thick. Would be nice to have a dropper bc it’s like a best guess on how much but what I’ve learned is that the sooner you get to it, the less you need and you can spot treat once it is totally clear. Life changing product when you love your pupper more than life. Worth every cent. I hope this review helps at least one other puppy and their pawrents that worry over them. Yes, bring your pets to the vet, but question them, and look for solutions rather than just going along with the plan. Find another vet that actually wants to prevent the problem, not just cytopoint it! Research it. AI is phenomenal now and we don’t just have to watch our pets suffer bc vets only have 15 min to talk to you; we can go in with questions and come to a holistic, preventative solution rather than just throwing antibiotics or allergy shots at everything.
A**R
This worked well!
My doggie had a persistent ear infection, and the vet bills were getting ridiculous. They kept prescribing steroids and expensive drops that worked for a while, but the problem kept recurring. The zymox cleared it up in a few days, she quit digging at it, and allowed me to use it on her with no struggle. It was helping her feel better and was soothing the nagging itching. Great product, at least for this doggie and her poor ear!
C**G
Pricey but it works!
My pug Sadie was constantly scratching her ears which kept us both up all night. I purchased several treatments over-the-counter and through Amazon. None of them worked. I was finally able to get her to the vet, they charged me to do a culture and administer medication in her ears. Two months later, she was scratching again. I purchased this product and within two days, her scratching has stopped and it’s been over a month. This product is a little pricey, but well worth it and much cheaper than what the vet charged me. Highly recommended!
S**2
One happy dog mom. This stuff is amazing!! 🙌🏻
This stuff works!!!! My beagle has ear issues with itching bad and the head shakes. I had her taken in to the vet and it was cleaned out with meds added and I left with $100 or more vet bill. My poor beagle had issues again months later so I looked on Amazon and found an ear flush that is amazing, but the issue wasn’t fully going away. I then found this product and gave it a try. No more vet visits this stuff cleared up her ear problems. It went from inflammation and dirty looking to a clear ear that is so clean and no issues. My sweet girl is so happy now. I highly recommend this product if your dog has itching, inflammation and the head shaking due to their ear bother them. I can’t believe how quickly and well this cleared my dog’s ear. It’s a heavier gel product too so it stays put. There’s also so much product to use. This will be a good thing to keep on hand instead of a vet visit for ear issues.
M**.
Yeast free after 4 yrs of constant expensive vet visits.
AMAZING. My great pyrenees struggled with frequent yeast in his right ear for YEARS... no more $400 vet appointment just to be back in another 4 weeks. This transformed his ear OVER NIGHT. He went from constant head shaking...to absolute silence. Hes comfortable. FINALLY! After 1 use, it made a visible and physical change. His ear went from red and angry to turning the normal white/pink as it should be. If youre like me, with a VET diagnosis of regular yeast issues...get it. Try it. My Jackathy is proof that this stuff works wonders. He isnt in pain anymore, he didnt even negatively react to having some goop in his ear.
T**S
Zymox ear solution with Cortizone
Best dog ear cleaner I have been able to find. I was previously using cleaner purchased from a veterinary office that only gave so-so results. This cleaner has a thicker consistency than most and contains hydrocortisone to relieve itching. My dog experiences reoccurring ear infections, but since using this for seven days, it has been five months since the ear infection has returned. Only negative for this product is that it’s thicker consistency tends to remain on the dogs ear flaps when they shake their head, allowing dust and dirt to accumulate. I recommend this product but caution, pet owners to make sure and wipe outside the air canal after dog has shaken their head.
F**T
Xymox really works!
My senior age pup's, 11yo lab-staffie+ hybrid, ears really cleared up: gunk, irritation/pawing of ears, alot less ear flapping. I would defininitely buy this product again. 👌😎
S**Y
must have!
This stuff is the absolute best. I have an English Bulldog, so he has frequent ear issues. This has cleared up ear infections beautifully. It's saved me money at the vet. 10/10
A**R
Cures ear infections at a low price
I haven’t had to go to the vet and pay hundreds of dollars for things to fix her ear infections since we got this stuff. I have a Chinese shar pei so it’s really common for them to get ear infections. This stuff is thick and doesn’t go everywhere, travels thru their ear and then you just wipe the excess. It’s great!
J**S
Great product. Solved my dog’s ear problem quickly.
Wow! My dog had what I interpreted as excessive wax build up in his ear. He’s a feisty little guy and I could not get on top of it with mere cleaning and hair trimming. With a yeasty smell I turned to this product. The debris that came out of his ear was phenomenal, and now he is irritation free with a very clean ear canal. This product is highly recommended.
B**Y
Cat yeasty ears
Had tried numerous different ways & products to rectify my cat’s yeasty ears which was giving her great irritation. Came across Zymox as a suggestion, applied once a day for 7 days- Problem solved immediately after one weeks use.! Even now a few weeks later she is irritation free and her ears are clear of black debris. Highly recommended.
J**I
Excellent
Excellent product as describe
G**S
great product , great service
great product , seems to be working fine
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